Aims Although methadone is widely used to treat opiate dependence, guidelines for its dosage are poorly defined. There is increasing evidence to suggest that a strategy based on plasma drug monitor

Thomas M. Polasek, Carl M. J. Kirkpatrick, and Amin Rostami-Hodjegan. Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation.

Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, practices, and opinions on MIPD while defining an achievable vision for MIPD in clinical care based 2012-12-13 · Background: Pregnancy is associated with considerable changes in the physiological, anatomical and biochemical attributes in women. These may alter the exposure to xenobiotics between pregnant and non-pregnant women who receive similar doses, with implications for different susceptibility to environmental pollutants or therapeutic agents. Title: Prediction of Intestinal First-Pass Drug Metabolism VOLUME: 8 ISSUE: 7 Author(s):Jiansong Yang, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Amin Rostami-Hodjegan is the author of ADME (0.0 avg rating, 0 ratings, 0 reviews, published 2009) and Biosimulation in Biomedical Research, Health Care Semantic Scholar profile for A. Rostami-Hodjegan, with 139 highly influential citations and 78 scientific research papers.

in Biomedical Research, Health Care and Drug Development [Elektronisk resurs] / edited by Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan. Författare: Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan; Format: Pocket/Paperback; ISBN: 9783709117644; Språk: Engelska; Antal sidor: 396 A Olivares-Morales, L Aarons, A Rostami-Hodjegan. Quantitative prediction of human oral bioavailability from animal bioavailability data: Comprehensive (Engelska)Ingår i: Biosimulation in biomedical research, health care and drug development / [ed] Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan, Rostami-Hodjegan, Amin. Univ Manchester, Manchester Pharm Sch, Ctr Appl Pharmacokinet Res, Manchester M13 9PT, Lancs, England.;Certara, Blades Mått, 235 × 155 × 25 mm. Vikt, 781 g. Språk, English.

Rapid turnover, a prominent feature of the enterocytes, has generally been ignored in the development Research Explorer.

Amin Rostami-Hodjegan, PhD, FCP, FAAPS, FJSSX. Amin is Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. In 2007, whilst working at the University of Sheffield, he was the first full Professor appointed with the title of Systems Pharmacology.

3Department of Pharmacology and Therapeutics (A.R.H., G.T.T.), Royal Hallamshire Hospital, Sheffield, in Biomedical Research, Health Care and Drug Development [Elektronisk resurs] / edited by Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan. Författare: Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan; Format: Pocket/Paperback; ISBN: 9783709117644; Språk: Engelska; Antal sidor: 396 Köp Biosimulation in Biomedical Research, Health Care and Drug Development av Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan på Bokus.com.

2018-03-27

Amin Rostami-Hodjegan. 3Department of Pharmacology and Therapeutics (A.R.H., G.T.T.), Royal Hallamshire Hospital, Sheffield, in Biomedical Research, Health Care and Drug Development [Elektronisk resurs] / edited by Erik Mosekilde, Olga Sosnovtseva, Amin Rostami-Hodjegan.
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Thomas M. Polasek, Carl M. J. Kirkpatrick, and Amin Rostami-Hodjegan. Therapeutic Advances in Drug Safety 2019 10.1177/2042098619894147 Download Citation. Model-informed precision dosing (MIPD) has become synonymous with modern approaches for individualizing drug therapy, in which the characteristics of each patient are considered as opposed to applying a one-size-fits-all alternative. This review provides a brief account of the current knowledge, pra … In vivo enzyme levels are governed by the rates of de novo enzyme synthesis and degradation. A current lack of consensus on values of the in vivo turnover half-lives of human cytochrome P450 (CYP) enzymes places a significant limitation on the accurate prediction of changes in drug concentration-tim … Amin Rostami-Hodjegan is Chief Scientific Officer at Certara USA, Inc. View Amin Rostami-Hodjegan’s professional profile on Relationship Science, the database of decision makers.

Title: Cytochrome P450 Turnover: Regulation of Synthesis and Degradation, Methods for Determining Rates, and Implications for the Prediction of Drug Interactions VOLUME: 9 ISSUE: 5 Author(s):Jiansong Yang, Mingxiang Liao, Magang Shou, Masoud Jamei, Karen Rowland Yeo, Geoffrey T. Tucker and Amin Rostami-Hodjegan Affiliation:Simcyp Limited, Blades Enterprise Centre, John Street, Sheffield S2 4SU Professor Amin Rostami‐Hodjegan, PharmD, PhD, FCP, Centre for Applied Pharmaceutical Research, Manchester Pharmacy School, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK. E‐mail: amin.rostami@manchester.ac.uk. Search for more papers by this author Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. He was the first full Professor appointed with the title of Systems Pharmacology. Professor Rostami in 2007 at the University of Sheffield.
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[1] Brahim Achour, Matthew R. Russel, Jill Barber, and Amin Rostami-Hodjegan, Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 59-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics, Drug Metab Dispos 42:500–510 (2014)

Corresponding Author. Amin Rostami-Hodjegan presented new approaches for the investigation of DDIs and showed that PBPK modeling information as part of NDA submissions increased dramatically (12 fold) in the last years. Additionally Mikko Niemi talked about active drug uptake by liver cells and what that means for drug-drug interactions. Adam S. Darwich, Kathryn Henderson, Angela Burgin, Nicola Ward, Janet Whittam, Basil J. Ammori, Darren M. Ashcroft & Amin Rostami-Hodjegan Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects Amin Rostami-Hodjegan, The University of Manchester, United Kingdom Amin is currently the Director of the Centre for Applied Pharmacokinetic Research (CAPKR) at the University of Manchester. He was the first full Professor appointed with the title of Systems Pharmacology.